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Provided by Nature Made
(C) Nature Made® SAM-E Complete® 400 mg., 60 Tablets
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  • Nature Made® SAM-E Complete®** 400 mg can help replenish your SAM-e levels and help support a healthy mood. Nature Made is the #1 best-selling brand of SAM-e supplements.‡  

    • 400 mg of SAM-e (S-adenosylmethionine Tosylate Disulfate)
    • Helps support a healthy mood & joint comfort
    • SAM-e can help support a healthy mood in as little as 7-14 days when taken daily
    • #1 Pharmacist Recommended Vitamin & Supplement Brand*
  • Factors such as age, certain health conditions and poor diet can impact the amount of SAM-e found in the body.

    SAM-e, or S-adenosylmethionine, is a compound naturally produced in the body that may increase levels of neurotransmitters, or brain chemicals, responsible for mood.†1 ,2 When levels are low, a SAM-e supplement can help restore the body’s supply of SAM-e.

    Therefore, SAM-e is recommended to help support a healthy mood. SAM-e has been shown to work in as little as 7 to 14 days when taken daily as directed. However, if you are experiencing symptoms of a low mood, see a physician for a proper guidance.

    SAM-e helps support joint comfort.†,3  SAM-e provides a source of dietary sulfur which plays a role in joint support. Sulfur is a mineral used by the body in connective tissue and joint cartilage.

  • Although generally considered as safe, SAM-e has not been evaluated in children or pregnant or lactating women. People with bipolar (manic) depression or who are experiencing severe issues with mood, including thoughts of suicide, should not take SAM-e except under a doctor's supervision.

    SAM-e should not be used when taking St. John's Wort. SAM-e should be used with caution and only under your healthcare provider's supervision when taking MAOI drugs, like Marplan, Nardil, Parnate, Manerix. Individuals on other medications should consult their primary healthcare provider prior to starting SAM-e to check for other potential interactions.
  • *#1 Brand of SAM-e supplements based on POS scan data at Food, Drug, Mass and Club.
    ** Complete because studies have shown that SAM-e helps support a healthy mood & joint comfort.†
  • Suggested Use: Start with 1 tablet per day. For easier swallowing, take with water before and during ingestion. The best time to take SAM-e is on an empty stomach at least 30 minutes before a meal. If benefits are not achieved within two weeks, you may require a higher level of supplementation. To determine the proper level of supplementation that works for you, gradually increase the number of tablets (maximum 1600 mg/day) until benefits are achieved.

    Ingredients: S-adenosylmethionine Tosylate Disulfate, Cellulose Gel, Methacrylic Acid Copolymer, Stearic Acid, Silicon Dioxide, Triethyl Citrate, Magnesium Stearate, Color Added (Titanium Dioxide), Mannitol, Sodium Starch Glycolate.

    NO Gluten, NO Yeast

    Interactions: People with bipolar (manic) depression or who are experiencing severe issues with mood, including thoughts of suicide, should not take this or any other product containing SAM-e except under a doctor’s supervision. If you are pregnant or nursing, or taking prescription antidepressant medications, consult your doctor before using this product.

    Keep out of reach of children.

    For Consumer Questions or Inquiries call 1-800-276-2878, or visit

  • Nature Made’s Commitment to your Health
    Everyone wants a firm foundation to stand upon when making decisions about their health. Since 1971, the Nature Made® brand has been dedicated to supporting your health with a wide range of high quality vitamin supplements. Because of our strong stand on quality and science for more than 40 years, Nature Made has earned recognition and trust among nutrition experts and people just like you.

    Safe and Quality Ingredients
    Nature Made products are made in accordance with strict Good Manufacturing Practice standards. Nature Made nutrition supplements are made from carefully selected ingredients from trusted suppliers. Nature Made products are guaranteed to meet high quality standards of purity and potency. When you take the vitamins behind that familiar yellow label, know that you’re taking the best for your health.
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